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| Product Name | FzM1 |
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| Description | Purity >95%. Wnt signaling proteins are small secreted proteins that are active in embryonic development, tissue homeostasis, and tumorigenesis. Wnt proteins initiate cell signaling by binding Frizzled (Fz) receptors, a family of G protein-coupled receptors. FzM1 is an allosteric ligand of Fz4. At 10 µM, it inhibits nuclear translocation of Beta-catenin in U87MG glioma cells treated with lithium chloride, a GSK3 inhibitor that enhances the Wnt canonical signaling pathway. FzM1 impairs the ability of U87MG cells to form neurospheres in culture and stimulates the differentiation of Caco-2 epithelial colorectal adenocarcinoma cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-hydroxy-5-(2-thienyl)phenyl]-N'-2-naphthalenyl-urea, Frizzled M1 |
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| Gene, Accession, CAS # | CAS: 1680196-54-6 |
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| Catalog # | LS-H7881 |
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| Price | |
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| Order / More Info | FzM1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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