| 产品详情 |
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| Antigenic Specificity | THEM4 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 20 µg/mL, Immunofluorescence: 20 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | THEM4 Polyclonal Antibody. THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depo |
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| Immunogen | n/a |
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| Other Names | CTMP; C-terminal modulator protein; carboxyl-terminal modulator protein |
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| Gene, Accession # | Entrez: 117145, 361992, 75778; Uniprot: Q3UUI3, Q566R0, Q5T1C6 |
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| Catalog # | PA5-20773 |
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| Price | |
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| Order / More Info | THEM4 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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