| 产品详情 |
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| Product Name | HPI-1 |
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| Description | Purity >95%. HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50 = 1.5 µM) without significantly affecting Wnt signaling (IC50 = 30 µM). HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor. HPI-1 also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,4,5,6,7,8-hexahydro-4-(3-hydroxyphenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-3-quinolinecarboxylic acid-2-methoxyethyl ester |
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| Gene, Accession, CAS # | CAS: 599150-20-6 |
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| Catalog # | LS-H8121 |
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| Price | |
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| Order / More Info | HPI-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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