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| Product Name | TNP-ATP (triethylammonium salt) |
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| Description | Purity >98%. TNP-ATP is a derivative of ATP and an antagonist at the purinergic receptor subtypes P2X1, P2X3, and P2X2/3 (IC50 s = 6, 0.9, and 7 nM, respectively). It is selective for those receptor subtypes over P2X2, P2X4, and P2X7 receptors (IC50 s = 2,000, 15,200, and >30,000 nM, respectively). TNP-ATP inhibits calcium flux in 1321N1 cells expressing P2X3 and P2X2/3 receptors (IC50 s = 10 and 62 nM, respectively). In a mouse model of visceral pain, TNP-ATP reduces acetic-acid induced writhing with an ED50 value of 6.35 µmol/kg. TNP-ATP is also a fluorescent probe for the activity of ATP-binding enzymes, such as insulin-degrading enzyme (IDE). It displays excitation/emission maxima of 403 and 547 nm, respectively, with a four-fold increase in fluorescence intensity and an emission shift to 538 nm when bound to IDE. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ((3a'R,4'R,6'R,6a'R)-4'-(6-amino-9H-purin-9-yl)-6'-(((((((hydroxyoxidophosphoryl)oxy)oxidophosphoryl)oxy)oxidophosphoryl)oxy)methyl)-2,6-dinitro-3a',4',6',6a'-tetrahydrospiro[cyclohexane-1,2'-furo[3,4-d][1,3]dioxole]-2,5-dien-4-ylidene)azinate, triethylte |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H10244 |
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| Order / More Info | TNP-ATP (triethylammonium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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