| 产品详情 |
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| Product Name | Crenolanib |
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| Description | Purity >95%. Crenolanib is an orally bioavailable, selective inhibitor of type III tyrosine kinases with nanomolar potencies against platelet-derived growth factor receptor Alpha (PDGFRAlpha) and PDGFRBeta and Fms-related tyrosine kinase 3 (FLT3; IC50 s = 11, 3.2, and 4 nM, respectively). It also inhibits medically-relevant mutant forms of these kinases, including the D842V-containing form of PDGFR and D835Y and internal tandem duplication mutations of FLT3, at nanomolar concentrations. Crenolanib is more than 100-fold selective for these kinases over other tyrosine and serine/threonine kinases. It is effective when used in cells and in vivo . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine, CP 868,596 |
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| Gene, Accession, CAS # | CAS: 670220-88-9 |
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| Catalog # | LS-H7262 |
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| Price | |
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| Order / More Info | Crenolanib from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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