| 产品详情 |
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| Product Name | Recombinant Human Prosaposin (PSAP), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 11.1kDa. Partial: 311-391aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase and galactosylceramide by beta-galactosylceramidase. Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A, GM1 gangliosides by beta-galactosidase and globotriaosylceramide by alpha-galactosidase A. Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator. Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | Proactivator polypeptide |
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| Gene, Accession, CAS # | PSAP, UniProt: P07602 |
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| Catalog # | RPC24901 |
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| Order / More Info | Recombinant Human Prosaposin (PSAP), partial from BIOMATIK |
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| Product Specific References | n/a |
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