| 产品详情 |
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| Product Name | PRL-3 Inhibitor |
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| Description | Purity >98%. Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro ), with minimal activity against other phosphatases. It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay. PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin Beta1 and modulates VEGF-mediated endothelial cell migration. It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone, BR-1, P0108, PTP4A3 Inhibitor, Phosphatase of Regenerating Liver 3 Inhibitor |
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| Gene, Accession, CAS # | CAS: 893449-38-2 |
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| Catalog # | LS-H9507 |
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| Order / More Info | PRL-3 Inhibitor from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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