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| Product Name | Diablo/SMAC, BioAssay™ ELISA Kit (Human) (Second Mitochondrial Activator of Caspase) |
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| Description | Diablo homolog, mitochondrial, also known as second mitochondria-derived activator of caspases(SMAC), is a protein that in humans is encoded by the DIABLO gene(direct IAP binding protein with low pI). It is mapped to 12q24.31. DIABLO can bind mammalian IAP homolog A(MIHA, or API3) and can also interact with MIHB, MIHC, and OpIAP, the baculoviral IAP. This gene encodes an inhibitor of apoptosis protein(IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Over expression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Sample Type: Cell culture supernates, serum and plasma (heparin, EDTA) Intended Use: For quantitative detection of human Diablo in cell culture supernates, serum and plasma (heparin, EDTA). Sensitivity: <10pg/ml Range: 31.2-2000pg/ml Specifici |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 56616, SwissProt: Q9NR28 |
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| Catalog # | 352821 |
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| Order / More Info | Diablo/SMAC, BioAssay™ ELISA Kit (Human) (Second Mitochondrial Activator of Caspase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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