| 产品详情 |
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| Product Name | TPEN |
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| Description | Purity >95%. As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions. Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral. At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation. At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N,N,N',N'-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine, TPEDA |
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| Gene, Accession, CAS # | CAS: 16858-02-9 |
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| Catalog # | LS-H10263 |
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| Order / More Info | TPEN from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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