| 产品详情 |
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| Product Name | SIRT1/2/3 pan Inhibitor |
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| Description | Purity ~97% (HPLC). A thienopyrimidinylcarboxamide that acts as a highly potent, reversible pan sirtuin (SIRT) inhibitor (IC50 = 15, 10, and 33nM for SIRT1, 2, and 3, respectively). Shown to bind to the SIRT catalytic site and occupy both the nicotinamide C-pocket and acetyl lysine substrate channel. Exhibits high selectivity over a panel of protein kinases, nuclelar receptors, GPCRs, and ion-channels (IC50 > 10uM). Poorly affects hERG and cytochrome P450s (> 50uM). Exhibits desirable stability in microsomal preparations (human CLint = 15.8 uL/min/mg, mouse CLint = 12.7uL/min/mg) and high solubility (297uM), and low LogD (2.73). Solubility: DMSO Primary Target: SIRT1/2/3 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | SIRT1/2/3 pan Inhibitor (pan SIRT1/2/3 Inhibitor, 4-(4-(2-Pivalamidoethyl)piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217792 |
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| Order / More Info | SIRT1/2/3 pan Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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