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| Product Name | RG-108 |
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| Description | Purity >98%. DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro ). It significantly reduces the methylation of genomic DNA in cells at 10 µM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine. Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site. Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | a-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-(aS)-1H-indole-3-propanoic acid, N-Phthalyl-L-tryptophan |
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| Gene, Accession, CAS # | CAS: 48208-26-0 |
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| Catalog # | LS-H9692 |
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| Order / More Info | RG-108 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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