| 产品详情 |
| Edit |   |
|---|
| Product Name | 7-alpha,25-dihydroxy Cholesterol |
|---|
| Description | Purity >94%. GPR183 (also known as Epstein-Barr virus-induced gene 2) is an orphan G protein-coupled receptor (GPCR) that is highly expressed in spleen and is required for humoral immune responses, including B cell migration and T cell-dependent antibody production. 7 alpha,25-dihydroxy Cholesterol (7 alpha,25-DHC) is a potent agonist of GPR183 that induces specific activation of the receptor with an EC50 value of 50 nM (Kd = 450 pM). At concentrations below 3 µM, it does not show any appreciable binding activity when tested against eight different nuclear hormone receptors including LXR and thirty-one different G protein-coupled receptors in a panel of reporter gene assays. 7 alpha,25-DHC can act as a potent chemokine, affecting migration of immune cells expressing GPR183 both in vitro (EC50 = 500 pM) and in vivo. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | (3-beta,7-alpha)-cholest-5-ene-3,7,25-triol, 7a,25-DHC |
|---|
| Gene, Accession, CAS # | CAS: 64907-22-8 |
|---|
| Catalog # | LS-H74 |
|---|
| Price | |
|---|
| Order / More Info | 7-alpha,25-dihydroxy Cholesterol from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|