| 产品详情 |
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| Product Name | Mdivi 1 |
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| Description | Purity >98%. Mitochondrial fusion and division proteins function via self assembly to regulate membrane dynamics during various cellular events. For example, the self assembly of dynamin-1, a mitochondrial protein that facilitates endocytosis, with a dynamin related-GTPase (Dnm1 (yeast)/Drp1(mammals)), a mitochondrial protein that functions during mitochondrial division, is thought to regulate apoptosis. Mdivi 1 is a quinazolinone derivative that selectively inhibits mitochondrial division by blocking dynamin GTPase activity in yeast (IC50 = 1-10 µM) and mammalian cells (IC50 = ~50 µM). It has been shown to prevent apoptosis by inhibiting mitochondrial outer membrane permeabilization in vivo and to block Bid-activated Bax/Bak-dependent cytochrome c release from mitochondria in vitro . It has been used to maintain mitochondrial integrity and to prevent cell death in models of pathological conditions including cancer, heart failure, and ischemia and reperfusion injuries. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-(2,4-dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone, Mitochondrial Division Inhibitor 1 |
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| Gene, Accession, CAS # | CAS: 338967-87-6 |
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| Catalog # | LS-H8613 |
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| Price | |
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| Order / More Info | Mdivi 1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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