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| Product Name | G-DNF (AA 78-211) (Active) protein |
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| Description | Glial cell line-derived neurotrophic factor (G-DNF) is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5,6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7].The recombinant human G-DNF expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ~30.4 kDa.Synonyms: Glial cell line-derived neurotrophic factor, ATF1, ATF2, HFB1-GDNF, HSCR3 |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | ABIN2017872 |
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| Order / More Info | G-DNF (AA 78-211) (Active) protein from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 2444978, 19381888, 19731553, 10829012, 11544105 |
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