| 产品详情 |
| Edit |   |
|---|
| Product Name | G-DNF (AA 78-211) (Active) protein |
|---|
| Description | Glial cell line-derived neurotrophic factor (G-DNF) is a neurotrophic factors belong to TGF-beta super family necessary for neuron survival and phenotypic maintenance in central and peripheral nervous systems [1]. G-DNF has the potent to support the differentiation and survival of many neuron subpopulations, prominent for dopaminergic neurons [2] and motor neurons [3], as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human [4]. GDNF has shown to interact with GFRA2 and GDNF family receptor alpha 1 [5,6]. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS) [7].The recombinant human G-DNF expressed in CHO cells is disulfide-linked homo-dimer, with an apparent molecular weight of ~30.4 kDa.Synonyms: Glial cell line-derived neurotrophic factor, ATF1, ATF2, HFB1-GDNF, HSCR3 |
|---|
| Size | 1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | ABIN2017870 |
|---|
| Price | |
|---|
| Order / More Info | G-DNF (AA 78-211) (Active) protein from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 2444978, 19381888, 19731553, 10829012, 11544105 |
|---|
| 产品资料 |
|
|