| 产品详情 |
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| Product Name | GDNF Family Receptor alpha 1 (GFRA1) (AA 25-429) protein (His tag) |
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| Description | Glial Cell Line-Derived Neurotrophic Factor Family Receptor alpha-1 (GDNFRalpha1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor alpha subtype which consists of at least four members. GFRalpha1and GFRalpha2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFRalphas released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFRalpha1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFRalpha1 shares 93% amino acid identity with mouse GFRalpha1.The expression of the various GFRalphas are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFRalphas in mediating the activities of the GDNF family of neurotrophic factors.Alternative Names: GDNF Family Receptor Alpha-1, GDNF Receptor Alpha-1, GDNFR-Alpha-1, GFR-Alpha-1, RET Ligand 1, TGF-Beta-Related Neurotrophic Factor Receptor 1, GFRA1, GDNFRA, RETL1, TRNR1 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | gdnfr|ret1l|retl1|trnr1|gdnfra|MGC122616|gfr-alpha-1|GFRA1|GDNFR|GDNFRA|GFR-ALPHA-1|RET1L|RETL1|TRNR1|GDNFRALPHA|AU042498 |
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| Gene, Accession, CAS # | Gene ID: 2674 |
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| Catalog # | ABIN1096733 |
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| Order / More Info | GDNF Family Receptor alpha 1 (GFRA1) (AA 25-429) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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