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| Product Name | GDNF Family Receptor alpha 2 (GFRA2) (AA 22-441) protein (His tag) |
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| Description | Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and Neurturin, play key roles in the control of vertebrate neuronal survivial and differentiation. GDNF is a glycosylated, disulfide-bonded homodimer that is distantly related to the TGF superfamily of growth factors. Three receptors for these factors, GFRalpha-1, GFRalpha-2, and GFRalpha-3 have been identified. The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosyl-phosphoinositol linkage. Both GFRalpha-1 and GFRalpha-2 have been shown to mediate the GDNF-dependent and Neurturin-dependent phosphorylation and activation of the tyrosine kinase Ret. GFR-3 is expressed only during development. GFRalpha-2 binds Neurturin and mediates activation of RET receptor tyrosine kinase by both Neurturin and GDNF.Alternative Names: GDNF Family Receptor Alpha-2, GDNF Receptor Alpha-2, GDNFR-Alpha-2, GFR-Alpha-2, GDNF Receptor Beta, GDNFR-Beta, Neurturin Receptor Alpha, NRTNR-Alpha, NTNR-Alpha, RET Ligand 2, TGF-Beta-Related Neurotrophic Factor Receptor 2, GFRA2, GDNFRB, RETL2, TRNR2 |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DKFZP459C0228|GFRA2|ntnra|retl2|trnr2|gdnfrb|nrtnr-alpha|gfra2|GDNFRB|NRTNR-ALPHA|NTNRA|RETL2|TRNR2|Retl2|NTNRALPHA |
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| Gene, Accession, CAS # | Gene ID: 2675 |
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| Catalog # | ABIN1096736 |
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| Order / More Info | GDNF Family Receptor alpha 2 (GFRA2) (AA 22-441) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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