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| Product Name | SU 4312 |
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| Description | Purity >98%. SU 4312 is a selective, cell-permeable inhibitor of VEGFR2 and PDGFR tyrosine kinases (IC50 s = 0.8 and 19.4 µM, respectively). It demonstrates IC50 values >100 µM at EGFR, HER2, and IGF-1R. SU 4312 has been shown to inhibit VEGF-dependent angiogenesis in a zebrafish assay (IC50 = 1.8 µM) without affecting normal cells. SU 4312 has also been shown to prevent MPP+ -induced neuronal apoptosis in vitro, as well as to decrease MPTP-induced loss of dopaminergic neurons, reduce expression of mRNA for tyrosine hydroxylase, and impair swimming behavior in zebrafish. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, NSC 86429 |
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| Gene, Accession, CAS # | CAS: 1429018 |
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| Catalog # | LS-H10054 |
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| Order / More Info | SU 4312 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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