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| Product Name | SU 6668 |
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| Description | Purity >98%. SU 6668 is an inhibitor of the receptor tyrosine kinases PDGFRBeta, VEGFR2, and FGFR1 (IC50 = 0.06, 2.4, and 3.0 µM, respectively) but not EGFR (IC50 >100 µM). Through these actions, SU 6668 suppresses tumor growth, blocks angiogenesis in tumors, and induces apoptosis of tumor vasculature and regression of established tumors. It also inhibits metastasis in a mouse orthotopic model of melanoma. SU 6668 also inhibits Aurora kinases B and C (IC50 = 35 and 210 nM, respectively) and may target other kinases. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid, NSC 702827, Orantinib, TSU-68 |
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| Gene, Accession, CAS # | CAS: 252916-29-3 |
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| Catalog # | LS-H10053 |
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| Order / More Info | SU 6668 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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