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| Product Name | SMER28 |
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| Description | Purity >98%. SMER28 is a small-molecule enhancer (SMER) of autophagy that increases autophagosome synthesis and enhances clearance of aggregate-prone substrates, including those relevant to Huntington's, Parkinson's, and Alzheimer's diseases. SMER28 induces clearance of amyloid-Beta (ABeta) peptides and the amyloid precursor protein c-terminal fragment (APP-CTF) in mouse embryonic fibroblasts (MEFs) isolated from wild-type, but not autophagy-related protein 5 knockout (Atg5-/- ), mouse embryos in a concentration-dependent manner. It induces autophagy independently of rapamycin in mammalian cells at a concentration of 47 µM. SMER28 also promotes reprogramming of fibroblasts into neural stem cells when used in combination with other chemical reagents. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-bromo-N-2-propen-1-yl-4-quinazolinamine |
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| Gene, Accession, CAS # | CAS: 307538-42-7 |
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| Catalog # | LS-H9947 |
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| Order / More Info | SMER28 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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