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| Product Name | DDR1-IN-1 (hydrate) |
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| Description | Purity >95%. The discoidin domain receptor (DDR) tyrosine kinases are activated by matrix collagens and are important for cell proliferation, differentiation, adhesion, migration, and invasion. DDR1-IN-1 binds to DDR1 and inhibits DDR1 autophosphorylation with an IC50 value of 105 nM and an EC50 value of 87 nM. It demonstrates weaker inhibition for DDR2 (IC50 = 413 nM) and has a good selectivity profile against a panel of 451 kinases. DDR-IN-1 has been shown to inhibit colorectal cancer cell lines when used in combination with the PI3K/mTOR inhibitor, GSK2126458 . |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[3-[(2,3-dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzamide, hydrate (4:3), Discoidin Domain Receptor 1-IN-1 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H7379 |
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| Price | |
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| Order / More Info | DDR1-IN-1 (hydrate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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