| 产品详情 |
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| Product Name | BGC 20-1531 (hydrochloride) |
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| Description | Purity >98%. BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2 ) receptor subtype 4 (EP4 ) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 µM. BGC 20-1531 antagonizes PGE2 -induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2 -induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2 -induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[[4-(5-methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide, monohydrochloride, PGN 1531 |
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| Gene, Accession, CAS # | CAS: 1962928-26-2 |
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| Catalog # | LS-H6779 |
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| Order / More Info | BGC 20-1531 (hydrochloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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