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| Product Name | XIB4035 |
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| Description | Purity >98% by NMR, TLC. XIB4035 is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRa-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50 = 10.4 uM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells. Recent studies indicate that it enhances GFRa family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease. GDNF agonists may be a new class of Parkinson's disease therapeutics. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4) |
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| Gene, Accession, CAS # | CAS: 10023-54-8 |
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| Catalog # | LS-H14891 |
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| Price | |
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| Order / More Info | XIB4035 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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