| 产品详情 |
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| Product Name | L-threo-Sphingosine C-18 |
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| Description | Purity >98%. Sphingosines are long-chain base precursors of cellular sphingolipids and are used directly in the synthesis of ceramide. Sphingosine can exist in four stereoisomers, however only D-erythro -sphingosine occurs naturally. L-threo -Sphingosine C-18, an analog of D-erythro -sphingosine, inhibits protein kinase C in mixed micelle assays with 50% inhibition at 2.2 mol % making it a slightly more potent inhibitor compared to D-erythro -sphingosine (50% inhibition at 2.8 mol %) or other analogs of shorter alkyl chain length. Addition of L-threo -Sphingosine C-18 to primary cultured cerebellar cells does not decrease serine palmitoyltransferase (SPT) activity, the rate-limiting enzyme in ceramide biosynthesis, whereas under similar conditions D-erythro -sphingosine inhibits SPT activity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2S-amino-4E-octadecene-1,3S-diol, L-threo-Sphingosine C18 |
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| Gene, Accession, CAS # | CAS: 25695-95-8 |
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| Catalog # | LS-H8532 |
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| Order / More Info | L-threo-Sphingosine C-18 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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