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| Product Name | Fatostatin (hydrobromide) |
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| Description | Purity >95%. Sterol regulatory element binding proteins (SREBPs) are transcription factors that have pivotal roles in lipogenesis and fat metabolism. The activation of SREBPs requires escort to the Golgi by SREBP cleavage-activating protein (SCAP) followed by proteolytic release of SREBP from the Golgi. Fatostatin is an inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC50 = 5.6 µM). This blocks constitutive SREBP-mediated gene expression in the human prostate cancer cell line DU145. Fatostatin prevents insulin-induced adipogenesis of 3T3-L1 cells as well as growth induced by insulin-like growth factor 1 in DU145 cells (IC50 = 0.1 µM). Through its actions on SCAP/SREBP-1, it inhibits high glucose-induced upregulation of TGF-Beta in primary rat mesangial cells. This compound also alters lipid metabolism in vivo, reducing hepatic fat accumulation in ob/ob mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(4-methylphenyl)-2-thiazolyl]-2-propyl-pyridine, hydrobromide, 125B11 |
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| Gene, Accession, CAS # | CAS: 298197-04-3 |
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| Catalog # | LS-H7758 |
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| Order / More Info | Fatostatin (hydrobromide) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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