| 产品详情 |
| Edit |   |
|---|
| Product Name | Recombinant Human Glucocorticoid receptor (NR3C1), partial |
|---|
| Description | Purity > 85% as determined by SDS-PAGE. MW: 47.8kDa. Partial: 521-777aa. N-terminal 6xHis-Trx-tagged. Homo sapiens (Human). Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling. Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth |
|---|
| Size | 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | RUO |
|---|
| Other Names | Nuclear receptor subfamily 3 group C member 1; GRL |
|---|
| Gene, Accession, CAS # | NR3C1, UniProt: P04150 |
|---|
| Catalog # | RPC25654 |
|---|
| Price | |
|---|
| Order / More Info | Recombinant Human Glucocorticoid receptor (NR3C1), partial from BIOMATIK |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|