| 产品详情 |
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| Antigenic Specificity | MB67 |
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| Clone | OTI2H10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100 µl |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2000 |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | MB67 Monoclonal Antibody (OTI2H10). This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compound |
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| Immunogen | n/a |
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| Other Names | Nuclear receptor subfamily 1 group I member 3, Constitutive activator of retinoid response, Constitutive active response, Constitutive androstane receptor, CAR, Orphan nuclear receptor MB67, NR1I3, CAR |
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| Gene, Accession # | Entrez: 9970; Uniprot: Q14994 |
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| Catalog # | MA5-26723 |
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| Price | |
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| Order / More Info | MB67 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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