| 产品详情 |
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| Product Name | SMI-481 |
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| Description | Purity >98%. Phosphatidylinositol (PtdIns) transfer proteins (PITPs) mediate the exchange of PtdIns and phosphatidylcholine between membranes, a step required for a wide array of cellular processes including cell division. SMI-481 is an inhibitor of the yeast PITP Sec14, blocking both Sec14-mediated transfer of [3 H]-PtdIns in vitro and growth (IC50 s = 0.21 and 2.87 µM, respectively). Suppression of Sec14 expression leads to proportional reduction in SMI-481 inhibition, suggesting that SMI-481 acts specifically through Sec14. Moreover, SMI-481 does not affect [3 H]-PtdIns transfer mediated by other yeast PITPs. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (4-chloro-3-nitrophenyl)[4-(2-fluorophenyl)-1-piperazinyl]-methanone |
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| Gene, Accession, CAS # | CAS: 432020-20-7 |
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| Catalog # | LS-H9951 |
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| Order / More Info | SMI-481 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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