| 产品详情 |
| Edit |   |
|---|
| Product Name | KH7 |
|---|
| Description | Purity >98%. Soluble adenylyl cyclase mediates bicarbonate-stimulated production of the ubiquitous second messenger adenosine 3',5'-cyclic mononucleotide (cAMP). It is abundantly expressed in sperm, in fluid transporting tissues such as kidney cortex and medulla, and in other bicarbonate-responsive tissues and cells. KH7 is a selective inhibitor of soluble adenylyl cyclase (sAC) that has little effect on transmembrane adenylyl cyclases. It displays an IC50 value between 3-10 µM toward sAC. At 50 µM, KH7 decreases basal cAMP accumulation in sperm. KH7 has been used in diverse research applications including cAMP-mediated signaling events required for mammalian egg fertilization, sAC regulation of Na+ transport in the kidney, and mitochondrial-dependent apoptosis in response to various stress stimuli. KH7 is not active against sAC in the presence of detergents. At concentrations above 50 µM, KH7 exhibits non-specific membrane disruption effects when used on cells. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 2-(1H-benzimidazol-2-ylthio)-2-[(5-bromo-2-hydroxyphenyl)methylene]hydrazide, propanoic acid |
|---|
| Gene, Accession, CAS # | CAS: 330676-02-3 |
|---|
| Catalog # | LS-H8343 |
|---|
| Price | |
|---|
| Order / More Info | KH7 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|