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| Product Name | GSK121 (trifluoroacetate salt) |
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| Description | Purity >98%. Protein arginine deiminase 4 (PAD4) mediates the transformation of protein arginine into citrulline. Citrullination of proteins has normal roles in gene regulation and pathological roles in immunological and inflammatory diseases. GSK121 is the initial compound identified in a screen for PAD4 inhibitors and was optimized to produce the more potent PAD4 inhibitors, GSK484 and GSK199 . GSK121 was shown to inhibit the citrullination of PAD4 target proteins in a functional assay with an IC50 value of 3.2 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (3-amino-1-piperidinyl)[1-methyl-2-(1-methyl-1H-indol-2-yl)-1H-benzimidazol-5-yl]-methanone, 2,2,2-trifluoroacetate |
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| Gene, Accession, CAS # | CAS: 1652591-80-4 |
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| Catalog # | LS-H7991 |
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| Order / More Info | GSK121 (trifluoroacetate salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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