| 产品详情 |
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| Product Name | 3-chloro-5-hydroxy BA |
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| Description | Purity >97%. GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 µM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 3-chloro-5-hydroxy-benzoic acid, 3-chloro-5-hydroxy BACHBAGPR81 Agonist |
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| Gene, Accession, CAS # | CAS: 53984-36-4 |
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| Catalog # | LS-H130 |
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| Order / More Info | 3-chloro-5-hydroxy BA from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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