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| Product Name | Human GDF10 / BMP3B Protein (Recombinant) |
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| Description | Purity >95% by SDS-PAGE and HPLC, MW: 25.1 kDa (SDS-PAGE). Bone Morphogenetic Protein-3B (BMP-3B) , also known as Growth/Differentiation Factor 10 (GDF-10), is a cytokine belonging to the Transforming Growth Factor Beta (TGF-Beta) superfamily. BMP-3B contains the cystine knot motif shared by other TGF-Beta family members. BMP-3B was originally identified by PCR based on the BMP-3 sequence, and shares 83% identity with BMP-3. BMP-3B and BMP-2 act as mutual antagonists, as they compete for the availability of signaling protein Smad4. In vivo, BMP-3B is highly expressed in brain, lungs, and bone tissues. The functions of BMP-3B include acting as a dorsaling factor in head development, inhibition of adipogenesis in adipocytes, and induction of bone formation. BMP-3B is down-regulated in lung cancer patient samples, indicating its potential antitumor activity. Recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 111 amino acids each. rhBMP-3B has a molecular mass of 25.1 kDa analyzed by non-reducing SDS-PAGE and is obtained by chromatographic techniques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GDF10, BMP-3b, Bone-inducing protein, BIP, BMP3B, Bone morphogenetic protein 3B, GDF-10 |
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| Gene, Accession, CAS # | GDF10, Gene ID: 2662 |
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| Catalog # | LS-G27213 |
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| Order / More Info | Human GDF10 / BMP3B Protein (Recombinant) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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