| 产品详情 |
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| Product Name | Gly-Phe-Beta-naphthylamide |
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| Description | Purity >95%. Cathepsin C is a lysosomal cysteine protease with broad exopeptidase activity that progressively removes dipeptides from various protein and polypeptides substrates. Aside from its role in post-translational processing, cathepsins may also participate in apoptotic signaling pathways by targeting cytosolic caspases and proapoptotic proteins. Gly-Phe-Beta-naphthylamide is a substrate of cathepsin C that accumulates within the lysosome. Hydrolysis by cathepsin C degrades Gly-Phe-Beta-naphthylamide into fragments that do not easily diffuse through the lysosomal membrane, leading to a loss of lysosome membrane integrity. This compound has been used to study intralysosomal hydrolysis, lysosomal membrane permeability, and the function of cathepsin C. At 50 µM, Gly-Phe-Beta-naphthylamide can inhibit the cathepsin-dependent activation of caspase-8. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | glycyl-N-2-naphthalenyl-L-phenylalaninamide, H-Gly-Phe-BNA |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | LS-H7966 |
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| Price | |
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| Order / More Info | Gly-Phe-Beta-naphthylamide from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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