| 产品详情 |
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| Product Name | GM 6001 |
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| Description | Purity >90%. GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 µM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (2R)-N4 -hydroxy-N1 -[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide, Galardin, Ilomastat |
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| Gene, Accession, CAS # | CAS: 142880-36-2 |
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| Catalog # | LS-H7967 |
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| Order / More Info | GM 6001 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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