| 产品详情 |
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| Product Name | PU-WS13 |
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| Description | Purity >98%. Glucose-regulated protein 94 (Grp94) is a stress-inducible molecular chaperone belonging to the heat shock protein (Hsp) family and, as a result, is also known as Hsp90B1. Grp94 is essential for the processing of proteins that have been implicated in tumorigenesis, including insulin-like growth factor 1 (IGF-1), Toll-like receptors (TLRs), and integrins. It also functions in antigen presentation, and its secreted form can elicit innate and adaptive immune responses. PU-WS13 is a cell-permeable inhibitor of Grp94 (EC50 = 220 nM). It displays selectivity for Grp94 over the related Hsps Trap-1, Hsp90Alpha, and Hsp90Beta. PU-WS13 blocks the proliferation of HER2 over-expressing SK-BR-3 cells in the sub-G1 phase and induces apoptosis, but doesn't significantly affect the survival of normal cells. It induces both apoptosis and necrosis in multiple myeloma cells but does not induce death in pre-B leukemic cells. Unlike pan-Hsp90 inhibitors, PU-WS13 does not activate a feedback heat-shock response. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine, WS13 |
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| Gene, Accession, CAS # | CAS: 1454619-14-7 |
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| Catalog # | LS-H9594 |
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| Price | |
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| Order / More Info | PU-WS13 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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