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| Product Name | Y320 |
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| Description | Purity >98%. IL-15 is a pro-inflammatory cytokine with roles in cancer and autoimmune diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, celiac disease, and alopecia areata. IL-15 can induce IL-17 production by CD4 T cells. Y320 is an inhibitor of the release of IL-17 by CD4 T cells stimulated with IL-15, either alone or in combination with CXCL12 and anti-CD3 monoclonal antibody (IC50 s = 57.4 and 25.7 nM, respectively). Oral administration of Y320 (0.3-3 mg/kg) reduces the expression of inflammatory cytokines, including IL-17, and inhibits joint destruction in type II collagen-induced arthritis (CIA) in mice. In this model, it acts synergistically with TNF-Alpha monoclonal antibody in ameliorating arthritis and joint destruction scores. Y320 also significantly reduces joint swelling in cynomolgus monkey CIA. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-(4-chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide |
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| Gene, Accession, CAS # | CAS: 288250-47-5 |
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| Catalog # | LS-H10535 |
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| Price | |
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| Order / More Info | Y320 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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