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| Product Name | LAG-3, Fc Chimera, Recombinant, Mouse (CD223, Lymphocyte Activation Gene-3) |
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| Description | Purity ~95% (SDSPAGE). LAG3 (Lymphocyte activation gene3), designated CD223, is a 70kD type I transmembrane protein that is a member of the immunoglobulin superfamily (IgSF) (1, 2). LAG3 shares ~20% amino acid sequence homology with CD4, but has similar structure and binds to MHC class II with higher affinity, providing negative regulation of T cell receptor signaling (1, 2). Mouse LAG-3 cDNA encodes 521 amino acids (aa) that include a 22aa signal sequence, a 420aa extracellular domain (ECD) with four Iglike domains, a transmembrane region and a highly charged cytoplasmic region. Within the ECD, mouse LAG3 shares 86% aa sequence identity with rat LAG3, and 65-69% with human, porcine, and bovine LAG3. LAG3 is expressed on activated CD4+ and CD8+ T cells, NK cells, and plasmacytoid dendritic cells (pDC), but not on resting T cells (13). LAG3 on activated CD4+CD25+ Treg cells plays a role in their suppressive activity (4). LAG3 limits the expansion of activated T cells and pDC |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q61790 |
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| Catalog # | 145815 |
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| Order / More Info | LAG-3, Fc Chimera, Recombinant, Mouse (CD223, Lymphocyte Activation Gene-3) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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