| 产品详情 |
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| Product Name | PSN375963 |
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| Description | Purity >97%. GPR119 (previously designated SNORF25) is an orphan G protein-coupled receptor expressed predominantly in the pancreas and gastrointestinal tract in humans and in the brain, pancreas, and gastrointestinal tract in rodents. It mediates a reduction in food intake and body weight gain in rats upon treatment with oleoyl ethanolamide (OEA), an endogenous, potent agonist for PPAR alpha . PSN375963 is a potent and selective agonist of GPR119 that shows similar potency to oleoyl ethanolamide (OEA) at both recombinant mouse and human GPR119 receptors, exhibiting EC50 values of 8.4 and 7.9 µM, respectively (EC50 values for OEA are 3.2 and 2.9 µM, respectively). These data suggest that PSN375963 may be useful as a therapeutic agent for the treatment of obesity. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[5-(4-butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine |
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| Gene, Accession, CAS # | CAS: 388575-52-8 |
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| Catalog # | LS-H20 |
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| Order / More Info | PSN375963 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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