| 产品详情 |
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| Product Name | SIRT1/2 Inhibitor IV |
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| Description | Purity >97%. SIRT1/2 inhibitor IV is a cell-permeable inhibitor of SIRT1 (IC50 = 56 µM) and SIRT2 (IC50 = 59 µM), blocking NAD+-dependent deacetylase activity in a substrate competitive manner. It less effectively inhibits SIRT5 (IC50 >300 µM) and has no effect on class I and II histone deacetylases. By inhibiting SIRT1, SIRT1/2 inhibitor IV sensitizes H460 lung cancer cells to etoposide and paclitaxel and enhances etoposide-induced G2 arrest. It also blocks a SIRT1-dependent hypoxic response in vivo, suppressing HIF-1 alpha protein accumulation as well as EPO and VEGF expression in HepG2 tumors in mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,3-dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1H)-pyrimidinone, Cambinol, NSC112546, SIRT1InhibitorII, SIRT2InhibitorVI |
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| Gene, Accession, CAS # | CAS: 14513-15-6 |
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| Catalog # | LS-H97 |
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| Order / More Info | SIRT1/2 Inhibitor IV from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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