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| Product Name | 2,4-Pyridinedicarboxylic Acid |
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| Description | Purity >98%. 2,4-Pyridinedicarboxylic Acid (2,4-PDCA) is a compound that structurally mimics 2-oxoglutarate (2-OG, also known as Alpha-ketoglutarate) and chelates zinc, thus affecting a range of enzymes. As a 2-OG mimic, it blocks the activity of 2-OG oxygenases, which include certain lysine demethylases and a variety of hydroxylases (e.g., prolyl, collagen, lysyl). 2,4-PDCA inhibits several Jumonji domain-containing lysine demethylases when used at low micromolar concentrations. Through its effects on hydroxylases, including prolyl hydroxlase 1 (IC50 = 1.5 µM), 2,4-PDCA modulates hypoxia-inducible factor turnover, collagen synthesis, and plant cell wall formation. It can inhibit zinc-dependent enzymes, like metallo-Beta-lactamase. 2,4-PDCA also affects and is translocated by organic anion transporters. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2,4-pyridinedicarboxylic acid, 2,4-Dicarboxypyridine, 2,4-PDCA, Lutidinic Acid, NSC 403248 |
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| Gene, Accession, CAS # | CAS: 499-80-9 |
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| Catalog # | LS-H5940 |
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| Order / More Info | 2,4-Pyridinedicarboxylic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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