| 产品详情 |
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| Product Name | SPD-304 |
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| Description | Purity >97%. Tumor necrosis factor alpha (TNF alpha) is a primary mediator of many inflammatory conditions including rheumatoid arthritis, toxic shock, and sepsis. TNF alpha functions as a trimer and promotes receptor trimerization to activate proinflammatory and/or apoptotic signalling pathways. SPD-304 is an inhibitor of tumor necrosis factor alpha (TNF alpha). that prevents binding to the TNF Receptor 1 (TNFR1) with an IC50 of 22 µM. It binds to the biologically active TNF alpha trimer and promotes accelerated displacement of a single subunit to rapidly inactivate the cytokine. In a cell based assay, SPD-304 inhibited TNF alpha -mediated stimulation of IKB degradation with an IC50 of 4.6 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6,7-dimethyl-3-[[methyl[2-[methyl[[1-[3-(trifluoromethyl)phenyl]-1H-indol-3-yl]methyl]amino]ethyl]amino]methyl]-4H-1-benzopyran-4-one |
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| Gene, Accession, CAS # | CAS: 869998-49-2 |
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| Catalog # | LS-H15 |
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| Price | |
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| Order / More Info | SPD-304 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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