| 产品详情 |
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| Product Name | Monastrol |
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| Description | Purity >98%. Monastrol is a reversible, cell-permeable inhibitor of the motor protein Eg5 (kinesin family protein 11, Kif11), blocking basal ATPase activity in vitro (IC50 = 6.1 µM) and inducing the formation of monoastral spindles in cell-based assays (IC50 = 51.3 µM). It arrests cells in mitosis without targeting tubulin and, as a result, does not interfere with microtubule dependent processes. Monastrol induces activation of the spindle assembly checkpoint and the resulting mitotic arrest can lead to cell death in certain tumor cell lines. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
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| Gene, Accession, CAS # | CAS: 329689-23-8 |
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| Catalog # | LS-H8792 |
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| Price | |
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| Order / More Info | Monastrol from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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