| 产品详情 |
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| Product Name | 3-Guanidinopropionic Acid |
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| Description | Purity >98%. 3-Guanidinopropionic acid is a creatine analog that alters skeletal muscle energy expenditure. It reduces cellular ATP, creatine, and phosphocreatine levels and stimulates AMP-activated protein kinase (AMPK), activating PPARGamma coactivator 1Alpha (PGC-1Alpha). PGC-1Alpha activation results in enhanced expression of AMPK, as well as genes for oxidative phosphorylation, electron transport chain, and mitochondrial biogenesis, increasing oxidative muscle fibers, numbers of mitochondria, and motor performance. 3-Guanidinopropionic acid evokes a shift from glycolytic to oxidative metabolism, increased cellular glucose uptake, and increased fatigue tolerance. In aged rats, reduced mitochondrial biogenesis in response to chronic activation of AMPK with 3-guanidinopropionic acid leads to metabolic insufficiency that can contribute to muscle loss. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-(aminoiminomethyl)-Beta-alanine, PNU 10483, -Beta-GPA |
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| Gene, Accession, CAS # | CAS: 353-09-3 |
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| Catalog # | LS-H6059 |
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| Order / More Info | 3-Guanidinopropionic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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