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| Product Name | R-Spondin 3, Human, BioAssay™ DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2) |
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| Description | R-Spondin 3 (RSPO3, Roof plate-specific Spondin 3), also called cysteine-rich and single thrombospondin domain containing-1 (Cristin 1), is an ~31kD secreted protein that shares ~40% aa identity with the other three R-Spondin family members. All are positive modulators of Wnt/beta-Catenin signaling, but each has a distinct expression pattern (1-4). Like other R-Spondins, R-Spondin 3 contains two adjacent cysteine-rich furin-like domains (amino acids (aa) 35-135) with one potential N-glycosylation site (36aa), followed by a thrombospondin (TSP-1) motif (aa147-207) and a region rich in basic residues (aa211-269). Only the furin-like domains are needed for beta-Catenin stabilization. Within aa21-209, mouse R-Spondin 3 shares 93%, 97%, 96%, 95% and 91% aa identity with human, rat, equine, bovine and canine R-Spondin 3, respectively. Potential isoforms of 217, 224 and 252aa are divergent or truncated at the C terminus; the 252aa form also lacks aa4-33 at the N-terminus. Mouse R-Spondin 3 is |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145765 |
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| Order / More Info | R-Spondin 3, Human, BioAssay™ DuoSet ELISA Development Kit (Cristin 1, PWTSR, RSPO3, THSD2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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