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| Product Name | Recombinant Human Complement C5 (C5), partial |
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| Description | Purity > 90% as determined by SDS-PAGE. MW: 12.3kDa. Partial: 678-751aa. N-terminal 6xHis-tagged. Homo sapiens (Human). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes (PubMed:8182049). C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | RUO |
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| Other Names | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 |
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| Gene, Accession, CAS # | C5, UniProt: P01031 |
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| Catalog # | RPC23809 |
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| Order / More Info | Recombinant Human Complement C5 (C5), partial from BIOMATIK |
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| Product Specific References | n/a |
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