| 产品详情 |
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| Product Name | Mutant IDH1-IN-1 |
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| Description | Purity >98%. Mutant IDH1-IN-1 is a selective inhibitor of the cancer-associated enzyme mutant isocitrate dehydrogenase 1 (IDH1) with IC50 values of 42, 4, and 80 nM for homozygous R132H and R132C mutant and heterozygous R132H wild-type enzymes, respectively, for converting Alpha-ketoglutarate (Alpha-KG) to 2-hydroxyglutaric acid (2-HG). It is selective for IDH1 mutant conversion of Alpha-KG to 2-HG over homozygous wild-type enzyme conversion of isocitrate to Alpha-KG (IC50 = 1,998 nM) and over IDH2 (IC50 s = >10,000 nM). Mutant IDH1-IN-1 inhibits 2-HG production in vitro (IC50 = 81.5 nM in HEK293 cells expressing IDH1R132H ). It allosterically binds to mutant IDH1 in a magnesium-dependent manner. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-1H-benzimidazole-1-acetamide |
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| Gene, Accession, CAS # | CAS: 1355326-21-4 |
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| Catalog # | LS-H8833 |
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| Order / More Info | Mutant IDH1-IN-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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