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| Product Name | Cdc42/Rac1 GTPase Inhibitor, ML141 |
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| Description | Purity ~99% (HPLC). A cell-permeable trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50=0.2, 2.6 and 5.4uM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50>100uM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPyS and PAK-PBD, and decrease GTP-Cdc42 (>95%) and GTP-Rac1 (>40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin-induced filopodia formation in 3T3 cells at 10uM. Formula: C22H21N3O3S Solubility: DMSO Molecular Weight: 407.5 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cdc42/Rac1 GTPase Inhibitor, ML141 (MLS00693334, CID2950007, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217263 |
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| Order / More Info | Cdc42/Rac1 GTPase Inhibitor, ML141 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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