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| Product Name | Asoxime (chloride) |
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| Description | Purity >95%. Organophosphates inactivate acetylcholinesterase (AChE) by reacting covalently with the active center serine, thus inhibiting its action of hydrolyzing acetylcholine at central and peripheral synapses. Acetylcholine accumulation results in an over-stimulation of cholinergic receptors, which can disrupt numerous biological functions. Asoxime is an asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates. It demonstrates therapeutic activity in experimental models of organophosphate poisoning, by reactivating phosphorylated AChE that was inhibited as a result of exposure to various cytotoxic nerve agents. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium, dichloride, HI-6 |
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| Gene, Accession, CAS # | CAS: 34433-31-3 |
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| Catalog # | LS-H6640 |
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| Order / More Info | Asoxime (chloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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