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| Product Name | CD275, Recombinant, Human, aa1-256 (B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1) |
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| Description | Purity ~98% (SDS-PAGE). Human B7-H2 is a member of the growing B7 family of immune costimulatory proteins. Other family members include B7-1, B7-2, B7-H1 (PD-L1), PD-L2 and B7-H3. B7 proteins are members of the immunoglobulin (Ig) superfamily, the extracellular domains contain 2 Ig-like domains and all members have short cytoplasmic domains. B7-H2 has been identified as the ligand for ICOS, a member of the CD28 family of costimulatory receptors. Human B7-H2 is expressed constitutively on resting B cells, dendritic cells and at low levels on monocytes. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation. Source: Recombinant protein corresponding to aa1-256 from human CD275, fused to the N-terminus of the Fc region of mouse IgG2a, expressed in CHO cells. Biological Activity: Measured by its ability to stimulate human T cell proliferation in the presence of anti-CD3. Endotoxin: ~0.06EU/ug protein (LAL test; Lonza) |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 207109 |
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| Order / More Info | CD275, Recombinant, Human, aa1-256 (B7-H2, ICOS Ligand, B7-like Protein Gl50, B7RP-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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