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| Product Name | B7H4, Recombinant, Human, His-Tag, aa29-258 |
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| Description | Purity ~95% (SDS-PAGE). B7-H4, also known as VTCN1, B7x and B7S1, is a 50-80kD glycosylated member of the BTN/MOG family of immunomodulatory protein (1, 2). Mature human B7-H4 consists of a 235aa extracellular domain (ECD) with one Ig-like V-set domain and one Ig-like C2-set domain, a 21aa transmembrane segment, and a 2aa cytoplasmic tail (3-5). Within the ECD, human B7-H4 shares 90% aa sequence identity with mouse and rat B7-H4. It shares 22%, 28% aa sequence identity with human B7-1, B7-2, B7-H1, B7-H2, B7-H3, and PD-L2. Alternate splicing of human B7-H4 generates an additional isoform that lacks the first Ig-like domain. B7-H4 is expressed on the surface of activated lymphocytes, macrophages, monocytes, dendritic cells, epithelial cells, and bone marrow- derived mesenchymal stem cells (4-8). Following binding to activated T cells, B7-H4 serves as a co-inhibitor of the T cell response. This is accomplished by reverse signaling that can induce either cell cycle arrest, or apoptosis in |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | B7H4, Recombinant, Human, His-Tag, aa29-258 (V-set Domain-containing T-cell Activation Inhibitor 1, B7h.5, Immune Costimulatory Protein B7-H4, Protein B7S1, T-cell Costimulatory Molecule B7x, VTCN1, UNQ659/PRO1291) |
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| Gene, Accession, CAS # | Accession: NP_078902 |
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| Catalog # | B0000-35G |
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| Order / More Info | B7H4, Recombinant, Human, His-Tag, aa29-258 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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